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KMID : 0861020090240040197
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Korea Journal of Herbology
2009 Volume.24 No. 4 p.197 ~ p.204
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Effect of New Herbal Mixture, HT008 on Arthritis Rat Model
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Lim Dong-Wook
Kim Mi-Yeon
Song Mi-kyoung
Kim Ji-Young
Lee Dong-Hun
Park Ju-Yeon
Bu Young-Min
Kim Ho-Cheol
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Abstract
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Objectives: This study was conducted to investigate the effect of HT008, a multi-herbal mixture consisting of 3 herbs, Eleutherococcus senticosus, Angelica sinensis, and Scutellaria baicaleinsis on arthritic model in rats.
Methods: The anti-inflammatory and analgesic activities were observed by utilizing the following models: carrageenan-induced edema of the hind paw of rats, acetic acid-induced writhing response in mice. The perimeter of the paw was measured before injection and then at 1, 2, 4, 6 h after injection of 1% λ-carrageenan. The HT008 at five dose levels (10, 30, 100, and 300 mg/kg) and distilled water given 30 min to treatment groups and control group, before λ-carrageenan injection. In the writhing test, the mice received 0.7% acetic acid solution in normal saline injected intraperitoneally at a dose of 10 ml/kg. The number of writhes was counted staring 10 min after injection.
Results: HT008 at four dose levels (30, 100, and 300 mg/kg) significantly decreased the carrageenan- induced rat paw edema perimeter. E. senticosus and S. baicaleinsis extracts reduced acetic acid-induced writhing response in mice. Also A. sinensis extracts significantly decreased the carrageenan-induced rat paw edema perimeter.
Conclusions: These results show that HT008, a multi-herbal mixture has both anti-inflammatory activity and analgesic effects in vivo arthritic model, and suggest that HT008 could be a good therapy to treat human osteoarthritis.
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KEYWORD
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HT008, anti-inflammation, paw edema, carrageenan, writhing syndrome, Eleutherococcus senticosus, Angelica sinensis, Scutellaria baicaleinsis
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